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 Isaac Hayes - Chef
Chef is the school cafeteria's chef. He is a big influence on the children. He teaches them lessons in life and helps them out. He sings songs about sex to explain to the kids complicated situations. He is a womanizer who firmly believes in the existence of extraterrestrials (visitors). He coaches the school sports teams, and led the hardball team to become World Hardball Champions.
 Cheech Marin - Carlos
Episode 407 - Cherokee Hair TamponsThis is Carlos, him and his friend Jesus (Chong) come to South Park selling their natural Indian medicines. The people of South Park find out that they're really not Indians they're Mexican.
 Dian Bachar - Chris
Episode 410 - Do the Handicapped go to Hell? -&- Episode 411 - PerhapsChris was Satan's new more compassionate lover. Saddam thinks he's a big pussy and kills him numerous times to get Satan all to himself.
 Robert Smith - Himself
Episode 112 - Mecha StriesandRobert comes to save South Park when it is attacked by that evil bitch Barbara Streisand. He morphs into Rob Mothera and with his super powerful robot punch Mecha-Streisand is blasted into outer space!
 Jonathan Katz - Himself
Episode 208 - Summer SucksHe was Mr. Garrison's psychiatrist when his "issues" get the most of him.
 Michael Buffer - Himself
Episode 108 - DamienHe plays the announcer in the Jesus Vs. Satan Pay-Per-View fight.
 Tommy Chong - Jesus
Episode 407 - Cherokee Hair TamponsThis is Jesus. Him and his friend Carlos (Cheech) start working for Mrs. Information in her South Park Holistic Healing shop when the people of South Park obsess over natural healing remedies.
 Jennifer Aniston - Mrs. Stevens
Episode 301 - Rainforest ShmainforestMrs. Stevens comes to South Park on the "Getting Gay With Kids" traveling kids Choir bus! She snatches the fearsome four and forces them to do choreography in the Costa Rican Rainforest. Mrs. Stevens is captured by the Yanagopa who dresses her in a cheer leader outfit.
 Mystery Guest - Ms. Ellen
Episode 111 - Tom's RhinoplastyShe substituted for Mr. Garrison when he got his nose job, but she turned out to be a full-time replacement until Mr. Garrison came back. She was a lesbian, but was accused by Wendy of trying to steal Stan away from her. Eventually it was revealed that the Iraqi government wanted her for spying and she was shot into the sun.
 Radiohead - Radiohead
Episode 501 - Scott Tenorman Must DieRadiohead comes to South Park because of a touching letter they recive from Cartman saying that his friend Scott Tenorman is dying. They show up to have a concert at Cartman's house, they think Scott Tenorman is a big lame crybaby.
 Mystery Guest - Mr. Kitty
Episode 113 - Cartman's Mom is a Dirty SlutMeow? No Kitty that's my pot pie!
 George Clooney - Sparky
Episode 104 - Big Gay Al's Big Gay BoatrideHe is Stan's gay dog. At first he is hated by Stan because of his homosexuality, so he flees to Big Gay Al's Animal Sanctuary where he can be accepted for what he is. In the end, Stan realizes his error and takes him back home. He also wears a pink bandanna.
 Korn - Themselves
Episode 312 - Korns Groovy Pirate Ghost MysteryKorn (Jonathan Davis, Fieldy, James Munky Shaffer, David Silveria, and Brian Head Welch) help the boys save South Park fight a spooky Pirate Ghost!
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